The same children’s eye drops sold in China contain preservatives, but those sold in Japan do not. Recently, Mentholatum’s brand Rohto Eye Drops was exposed to double standards, causing widespread concern among consumers. Industry insiders pointed out that although Rohto eye drops contain preservatives and are in line with domestic standards, Mentholatum’s move does implement a double standard.
In this regard, Japan Rohto Pharmaceutical Co., Ltd. and Mentholatum (China) Pharmaceutical Co., Ltd. jointly issued a statement, acknowledging that Rohto eye drops sold in the Chinese market have added antiseptic It is currently exploring the feasibility of launching preservative-free eye drops in China.
◇Exposure that China’s Rohto eye drops are all preservatives
A reporter from Nanfang Daily logged onto Mentholatum’s official website and saw that Rohto drops sold in the Chinese market There are five main types of eye drops, namely Xin Le Dun, Xiao Le Dun, Le Dun Qing, Le Dun Ying and Le Dun Kang, all of which are produced by Mentholatum (China) Pharmaceutical Co., Ltd. for OTC topical drugs.
When visiting several major pharmacies in Guangzhou, the reporter saw that the above five products were on sale, and the ingredients on their product packaging showed that all of them were added with preservatives. Among them, Xiao Le Dun, Xin Le Dun, Le Dun Kang added benzalkonium chloride solution, Le Dun Ying added concentrated chlorinate solution 50 (same as benzalkonium chloride), and Le Dun Qing added Potassium sorbate.
data show that benzalkonium chloride, concentrated chlorinated hydrochloride solution 50, potassium sorbate are widely used in “preservative”, preservatives contain this ingredient. In these five products, the names of the preservatives are all listed in the ingredients of the excipients, and people who lack chemical knowledge cannot identify them at all.
According to industry insiders, adding preservatives to eye drops is a common phenomenon in the industry, and the reporter also found during the interview that the eye drops sold by multiple brands contain preservatives such as benzalkonium chloride. . It is understood that according to my country’s “Administrative Measures for Pharmaceutical Excipients”, preservatives can be used as antibacterial excipients in eye drops. Generally speaking, medicines that do not contain preservatives have stricter packaging and smaller capacity.
It is understood that most of the preservative-free eye drops sold in China are single-packed, each can only be used within one day, and the price is generally relatively expensive. Although the preservative-free eye drops can also be bought in domestic pharmacies, due to the difference in storage time and price, relative sales will be affected.
◇Question about the same Japanese eye drops without preservatives
According to media reports, ROHTO’s eye drops products on the market in Japan are more abundant than those in China. Most products also contain preservatives, which means that preservatives are also allowed to be added to eye drops in Japan.
However, it is worth noting that ROHTO launched in Japan two products for children under 15 years old (Kodomo soft, children’s comfort type) and teenagers (JR, teenagers) on the packaging box , Are clearly marked that no preservatives are added. Similar products sold in China contain preservatives.
According to a reporter from the Nanfang Daily, the production place of Rohto eye drops on sale in China is Zhongshan, Guangdong, and its subsidiary company is Mentholatum (China). According to the official website, “The production equipment is made by American Mentholatum and Introduced by ROHTO Pharmaceutical Factory in Japan”. Mentholatum (China) is a wholly-owned company of Mentholatum of the United States in China. Currently Mentholatum of the United States has been acquired by Rohton Pharmaceuticals. Japan’s ROHTO eye drops are all produced by Japan’s ROHTO Pharmaceutical Factory.
Since the company can produce preservative-free products, why do China and Japan still implement double standards? In response to this question, on April 10, ROHTO Pharmaceutical Co., Ltd. of Japan and Mentholatum (China) Pharmaceutical Co., Ltd. jointly issued a statement stating that Rhodon eye drops sold in the Japanese market were the second product produced by ROHTO Pharmaceuticals in Japan. A new product without preservatives. The Xiao Le Dun eye drops in the Chinese market are the first-generation products produced by Mentholatum (China). The prescriptions used for the Xiao Le Dun eye drops in China and Japan are different.
The statement also stated that the preservatives used by Xiao Le Dun meet statutory standards. The correct use of the product in accordance with the instructions or the doctor’s advice will not cause adverse effects on consumers. The statement also stated that due to the different pharmaceutical regulations in different countries, Mentholatum (China) Pharmaceutical Co., Ltd. is also exploring the feasibility of launching preservative-free eye drops in China.
◇Danger preservatives or affect children’s corneal development
eye drops contain preservatives, how harmful is it?
In response, Tang Xilan, director of the Department of Pharmacy of Sun Yat-sen University’s Zhongshan Ophthalmology Center, said that there are hundreds of eye drop products on the market, and more than 95% of them contain preservatives. At the same time, the state clearly stipulates that eye drops can be added with preservatives, and there are strict dosage requirements, so consumers do not need to panic too much.
According to Tang Xilan, the presence of preservatives can effectively prevent microbial contamination from contact with air and human body after eye drops are opened. Short-term and intermittent use of such eye drops will not cause adverse effects on consumers of.