Doctor of Clinical Pharmacy, Zhongda Hospital, Southeast University, Niu Yimin
You must take medicine when you are sick, but medicine and food take a “one way” in the body. Digestion, absorption, metabolism, and excretion tend to gather in the gastrointestinal tract, so the two must influence each other. When taking medicine, you should have an understanding of the relationship between medicine and food, you can maximize its efficacy, and avoid the “conflict” between food and medicine and cause toxic side effects. For example, the following 4 kinds of drugs have their food “good partners” respectively.
A good partner for statins: vegetable oil. Statin is a commonly used lipid-lowering drug. During the period of taking it, patients with hyperlipidemia can make the drug more effective if they are accompanied by food. Vegetable oil has the effect of strengthening statins to lower cholesterol. The plant sterols are similar in structure to cholesterol and can compete for the body’s absorption of cholesterol. Eating legumes and using vegetable oils in cooking can enhance the lipid-lowering effect of statins without obvious side effects.
Note: During the period of taking statins, you should avoid eating citrus fruits and pomegranates. They can affect the effectiveness of drugs and may cause some side effects.
A good partner for antihypertensive drugs: high-fiber foods. When taking antihypertensive drugs, you may wish to match high-fiber foods to promote gastrointestinal motility and increase bioavailability. Common high-fiber foods include: coarse grains, such as soybeans, oats, wheat, corn, etc.; vegetables include celery, spinach, rape, cabbage, cauliflower, etc.; others include apples, carrots, bamboo shoots, pumpkins, shiitake mushrooms, barley, black beans , Peas, bitter gourd, etc.
Note: Avoid drinking grapefruit juice and foods with high salt content while taking antihypertensive drugs and anti-angina drugs. Naringenin in grapefruit juice can affect the action of certain enzymes in the liver, and this enzyme is precisely related to the metabolism of blood pressure and anti-angina drugs. In addition, drink tea or coffee at least 30 minutes after taking the medicine. The tannic acid contained in green tea easily reacts with drugs to form insoluble substances. The caffeine contained in it promotes gastric acid secretion and has a certain stimulating effect on the gastric mucosa.
Good vitamin partner: fat. Fat-soluble vitamins (A, D, E) are insoluble in water, but easily soluble in fat. Taken after a meal, with the participation of oils, they will stay in the stomach for a longer time and be absorbed more fully.
Note: Fat intake should be moderate, not to eat greasy food to promote vitamin absorption.
A good partner for diuretics: potatoes. During the period of taking diuretics, hypertensive patients can eat more foods rich in potassium to make up for the loss of potassium and reduce the adverse effects of antihypertensive drugs. Potatoes are a common potassium-rich food, ranking first in the vegetable category. Other fruits and vegetables such as winter melon, watermelon, almonds, oranges, grapes are also rich in potassium, and eating some can avoid hypokalemia.